Metamenu

Model Internals

Each PhenDB model is trained on sets of bacterial ENOGs (orthologous groups from EggNOG 4.5), which have or have not been identified in the training genomes. Each ENOG is given a weight, with the magnitude of the weight being the importance of that ENOG for the final prediction. The sign of the weight indicates whether the presence (positive weight) or absence (negative weight) of this ENOG is indicative of the trait.

This table lists the 250 highest-ranking ENOGs of this model.

rank in model enog name enog description weight in model
1 COG0287 Prephenate dehydrogenase -0.020239
2 COG2150 ACT domain -0.017302
3 COG0133 tryptophan synthase activity -0.016293
4 COG0726 polysaccharide deacetylase -0.015847
5 COG2927 DNA polymerase III (CHI subunit) 0.015256
6 COG0440 acetolactate synthase activity -0.015113
7 COG0031 Belongs to the cysteine synthase cystathionine beta- synthase family -0.014968
8 COG0134 indole-3-glycerol-phosphate synthase activity -0.014333
9 COG3127 ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component -0.013916
10 COG1636 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) -0.013727
11 COG0169 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) -0.013526
12 COG0826 peptidase U32 -0.013332
13 COG0843 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B 0.013319
14 COG1622 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor 0.013319
15 COG1845 cytochrome c oxidase, subunit III 0.013319
16 COG0853 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine -0.013255
17 COG3226 Transcriptional regulator -0.013148
18 COG2252 PERMEase -0.013100
19 COG0652 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides -0.013074
20 COG0052 Belongs to the universal ribosomal protein uS2 family 0.013053
21 COG0159 tryptophan synthase activity -0.013021
22 COG0325 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis -0.012913
23 COG0345 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline -0.012865
24 COG0091 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome 0.012821
25 COG0333 Belongs to the bacterial ribosomal protein bL32 family 0.012648
26 COG0251 oxidation-reduction process -0.012616
27 COG0379 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate -0.012500
28 COG0275 rRNA processing 0.012490
29 COG0547 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) -0.012444
30 COG0048 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit 0.012435
31 COG0051 transcription antitermination factor activity, RNA binding 0.012435
32 COG0080 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors 0.012435
33 COG0085 RNA polymerase activity 0.012435
34 COG0087 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit 0.012435
35 COG0090 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity 0.012435
36 COG0092 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation 0.012435
37 COG0093 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome 0.012435
38 COG0094 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits 0.012435
39 COG0097 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center 0.012435
40 COG0099 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits 0.012435
41 COG0100 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome 0.012435
42 COG0185 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA 0.012435
43 COG0186 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA 0.012435
44 COG0197 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs 0.012435
45 COG0199 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site 0.012435
46 COG0202 RNA polymerase activity 0.012435
47 COG0211 Belongs to the bacterial ribosomal protein bL27 family 0.012435
48 COG0227 Belongs to the bacterial ribosomal protein bL28 family 0.012435
49 COG0228 four-way junction DNA binding 0.012435
50 COG0261 This protein binds to 23S rRNA in the presence of protein L20 0.012435
51 COG0292 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit 0.012435
52 COG0305 Participates in initiation and elongation during chromosome replication 0.012435
53 COG0361 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex 0.012435
54 COG0443 Heat shock 70 kDa protein 0.012435
55 COG0480 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome 0.012435
56 COG0522 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit 0.012435
57 COG0587 DNA-directed DNA polymerase activity 0.012435
58 COG0691 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene 0.012435
59 COG0673 inositol 2-dehydrogenase activity -0.012411
60 COG0365 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA -0.012403
61 COG0014 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate -0.012402
62 COG0414 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate -0.012394
63 COG1052 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family -0.012369
64 COG0096 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit 0.012344
65 COG0098 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body 0.012344
66 COG0102 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly 0.012344
67 COG3125 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor 0.012321
68 COG0174 glutamine synthetase -0.012185
69 COG0088 Forms part of the polypeptide exit tunnel 0.012056
70 COG0290 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins 0.012056
71 COG0576 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ 0.012056
72 COG0347 Belongs to the P(II) protein family -0.011991
73 COG0482 sulfurtransferase activity 0.011888
74 COG0200 Binds to the 23S rRNA 0.011865
75 COG1702 phosphate starvation-inducible protein PhoH -0.011817
76 COG0532 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex 0.011812
77 COG0508 dehydrogenase complex catalyzes the overall conversion of 0.011751
78 COG0316 Belongs to the HesB IscA family 0.011737
79 COG0413 3-methyl-2-oxobutanoate hydroxymethyltransferase activity -0.011722
80 COG0239 Important for reducing fluoride concentration in the cell, thus reducing its toxicity -0.011695
81 COG2084 Dehydrogenase -0.011683
82 COG0254 rRNA binding 0.011672
83 COG0824 Thioesterase -0.011606
84 COG1454 alcohol dehydrogenase -0.011530
85 COG0067 glutamate synthase -0.011459
86 COG1089 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose -0.011455
87 COG0184 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome 0.011437
88 COG0257 Belongs to the bacterial ribosomal protein bL36 family 0.011421
89 COG0789 Transcriptional regulator -0.011413
90 COG0034 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine -0.011323
91 COG0041 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) -0.011323
92 COG0047 phosphoribosylformylglycinamidine synthase activity -0.011323
93 COG0263 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate -0.011278
94 COG0050 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis 0.011272
95 COG0062 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration -0.011213
96 COG0135 phosphoribosylanthranilate isomerase activity -0.011204
97 COG0267 Belongs to the bacterial ribosomal protein bL33 family 0.011190
98 COG1191 sigma factor activity -0.011125
99 COG0785 Cytochrome C biogenesis protein -0.011112
100 COG1995 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) -0.011083
101 COG0049 tRNA binding 0.011069
102 COG3830 Belongs to the UPF0237 family -0.010980
103 COG1918 ferrous iron import across plasma membrane -0.010974
104 COG0445 tRNA wobble uridine modification 0.010947
105 COG1045 serine acetyltransferase -0.010919
106 COG2022 thiamine diphosphate biosynthetic process -0.010896
107 COG2021 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine -0.010873
108 COG1605 Chorismate mutase -0.010854
109 COG0402 S-adenosylhomocysteine deaminase activity -0.010819
110 COG2913 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane 0.010795
111 COG0568 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released 0.010789
112 COG0538 isocitrate dehydrogenase activity -0.010757
113 COG0179 Fumarylacetoacetate (FAA) hydrolase -0.010722
114 COG0129 dihydroxy-acid dehydratase activity -0.010663
115 COG0640 Transcriptional regulator -0.010599
116 COG0151 Belongs to the GarS family -0.010580
117 COG4172 Belongs to the ABC transporter superfamily -0.010531
118 COG1193 negative regulation of DNA recombination -0.010517
119 COG0077 Prephenate dehydratase -0.010514
120 COG0299 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate -0.010487
121 COG1301 dicarboxylic acid transport 0.010472
122 COG0004 ammonium transporteR -0.010422
123 COG1666 GTP binding -0.010399
124 COG0836 Belongs to the mannose-6-phosphate isomerase type 2 family -0.010353
125 COG1521 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis -0.010255
126 COG0847 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease 0.010250
127 COG0648 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin 0.010232
128 COG0432 Pfam Uncharacterised protein family UPF0047 -0.010208
129 COG0601 transmembrane transport -0.010194
130 COG0138 bifunctional purine biosynthesis protein purh -0.010181
131 COG0634 Belongs to the purine pyrimidine phosphoribosyltransferase family -0.010149
132 COG2133 pyrroloquinoline quinone binding -0.010147
133 COG0086 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates 0.010122
134 COG0800 Aldolase -0.010120
135 COG0335 large ribosomal subunit rRNA binding 0.010090
136 COG0546 phosphoglycolate phosphatase activity -0.010089
137 COG1080 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) -0.010079
138 COG2608 mercury ion transmembrane transporter activity -0.010069
139 COG1912 Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase -0.010062
140 COG1959 2 iron, 2 sulfur cluster binding -0.010018
141 COG0234 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter 0.010013
142 COG0633 Ferredoxin 0.009991
143 COG2249 NAD(P)H dehydrogenase (quinone) activity -0.009958
144 COG0459 protein refolding 0.009939
145 COG0157 Belongs to the NadC ModD family -0.009920
146 COG0173 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) 0.009905
147 COG0746 molybdenum cofactor guanylyltransferase activity -0.009888
148 COG1610 YqeY-like protein -0.009844
149 COG2770 Histidine kinase -0.009782
150 COG1778 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate -0.009777
151 COG1296 Branched-chain amino acid permease (Azaleucine resistance) -0.009776
152 COG4839 cell division protein FtsL -0.009768
153 COG0428 transporter -0.009742
154 COG0566 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family 0.009697
155 COG0386 Belongs to the glutathione peroxidase family -0.009681
156 COG0038 chloride channel -0.009664
157 COG0535 radical SAM domain protein -0.009654
158 COG0230 Belongs to the bacterial ribosomal protein bL34 family 0.009630
159 COG0284 orotidine-5'-phosphate decarboxylase activity -0.009630
160 COG1160 GTP binding 0.009624
161 COG0002 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde -0.009598
162 COG0466 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner 0.009590
163 COG1723 PFAM Uncharacterised ACR, YagE family COG1723 0.009585
164 COG1368 sulfuric ester hydrolase activity -0.009548
165 COG0667 Aldo Keto reductase -0.009545
166 COG0005 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate -0.009539
167 COG1989 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue -0.009526
168 COG0351 phosphomethylpyrimidine kinase -0.009520
169 COG0123 including yeast histone deacetylase and acetoin utilization protein -0.009510
170 COG0540 Belongs to the ATCase OTCase family -0.009504
171 COG2189 Belongs to the N(4) N(6)-methyltransferase family -0.009483
172 COG1208 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon -0.009477
173 COG0119 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) -0.009447
174 COG1249 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family 0.009402
175 COG0370 Transporter of a GTP-driven Fe(2 ) uptake system -0.009380
176 COG0293 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit 0.009370
177 COG3448 diguanylate cyclase activity -0.009364
178 COG1847 R3H domain protein -0.009347
179 COG1364 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate -0.009328
180 COG2127 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation -0.009311
181 COG0362 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH 0.009306
182 COG2873 o-acetylhomoserine -0.009294
183 COG0019 diaminopimelate decarboxylase activity -0.009275
184 COG3202 ADP transmembrane transporter activity 0.009267
185 COG1011 Hydrolase -0.009266
186 COG0735 belongs to the Fur family -0.009265
187 COG3837 Cupin domain -0.009259
188 COG2104 thiamine diphosphate biosynthetic process -0.009259
189 COG5002 protein histidine kinase activity -0.009248
190 COG1473 amidohydrolase -0.009218
191 COG2957 Belongs to the agmatine deiminase family -0.009194
192 COG0165 Argininosuccinate lyase -0.009168
193 COG2510 membrane -0.009161
194 COG0564 pseudouridine synthase activity 0.009143
195 COG2827 Endonuclease containing a URI domain -0.009135
196 COG0791 NLP P60 protein -0.009122
197 COG2151 metal-sulfur cluster biosynthetic enzyme -0.008995
198 COG0605 Destroys radicals which are normally produced within the cells and which are toxic to biological systems 0.008961
199 COG0533 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction 0.008955
200 COG3967 Belongs to the short-chain dehydrogenases reductases (SDR) family -0.008954
201 COG3167 carbon utilization -0.008903
202 COG1216 Glycosyl transferase, family 2 -0.008844
203 COG0066 3-isopropylmalate dehydratase activity -0.008836
204 COG3960 tartronate-semialdehyde synthase activity -0.008811
205 COG2951 lytic endotransglycosylase activity -0.008802
206 COG0109 protoheme IX farnesyltransferase activity 0.008755
207 COG0730 response to heat -0.008748
208 COG1125 glycine betaine transport -0.008737
209 COG1174 glycine betaine transport -0.008737
210 COG4221 oxidoreductase activity -0.008734
211 COG0683 leucine binding -0.008715
212 COG2759 Belongs to the formate--tetrahydrofolate ligase family -0.008683
213 COG4966 pilus assembly protein PilW -0.008665
214 COG0539 negative regulation of cytoplasmic translation 0.008664
215 COG2921 Belongs to the UPF0250 family -0.008657
216 COG0659 secondary active sulfate transmembrane transporter activity -0.008655
217 COG0476 Involved in molybdopterin and thiamine biosynthesis, family 2 -0.008634
218 COG4166 transmembrane transport -0.008630
219 COG0291 Belongs to the bacterial ribosomal protein bL35 family 0.008619
220 COG0510 thiamine kinase activity 0.008616
221 COG4968 Prepilin-type N-terminal cleavage methylation domain -0.008605
222 COG0315 cyclic pyranopterin monophosphate synthase activity -0.008584
223 COG2896 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate -0.008584
224 COG0008 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) 0.008552
225 COG0060 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) 0.008552
226 COG0172 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) 0.008552
227 COG0233 cytoplasmic translational termination 0.008552
228 COG0358 DNA primase activity 0.008552
229 COG0013 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain 0.008552
230 COG0105 UTP biosynthetic process 0.008525
231 COG0410 ABC transporter -0.008501
232 COG0411 ABC transporter -0.008483
233 COG0059 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate -0.008482
234 COG0525 valine-tRNA ligase activity 0.008477
235 COG3133 Outer membrane lipoprotein 0.008469
236 COG1254 Belongs to the acylphosphatase family -0.008447
237 COG0344 acyl-phosphate glycerol-3-phosphate acyltransferase activity -0.008428
238 COG2905 signal-transduction protein containing cAMP-binding and CBS domains -0.008425
239 COG0150 phosphoribosylformylglycinamidine cyclo-ligase activity -0.008413
240 COG1219 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP 0.008408
241 COG0069 glutamate synthase activity -0.008391
242 COG0124 histidyl-tRNA synthetase 0.008373
243 COG0143 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation 0.008373
244 COG0162 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) 0.008373
245 COG0180 Tryptophanyl-tRNA synthetase 0.008373
246 COG0015 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily -0.008370
247 COG1765 OsmC-like protein -0.008358
248 34CD0 Thioredoxin 0.008345
249 COG0203 ribosomal protein L17 0.008342
250 COG0238 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit 0.008342