Model Internals

Each PhenDB model is trained on sets of bacterial ENOGs (orthologous groups from EggNOG 4.5), which have or have not been identified in the training genomes. Each ENOG is given a weight, with the magnitude of the weight being the importance of that ENOG for the final prediction. The sign of the weight indicates whether the presence (positive weight) or absence (negative weight) of this ENOG is indicative of the trait.

This table lists the 250 highest-ranking ENOGs of this model.

rank in model enog name enog description weight in model
1 COG0568 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released -0.036631
2 COG0513 Belongs to the DEAD box helicase family -0.033416
3 COG0736 holo-[acyl-carrier-protein] synthase activity -0.030954
4 COG0358 DNA primase activity -0.029102
5 COG2110 phosphatase homologous to the C-terminal domain of histone macroH2A1 0.028434
6 COG4591 ABC-type transport system involved in lipoprotein release permease component -0.028074
7 COG1514 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester 0.027763
8 COG3591 Belongs to the peptidase S1B family -0.027166
9 COG2249 NAD(P)H dehydrogenase (quinone) activity -0.025754
10 COG0571 ribonuclease III activity -0.025418
11 COG0230 Belongs to the bacterial ribosomal protein bL34 family -0.025071
12 COG0262 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis -0.024929
13 COG0692 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine -0.024894
14 COG0489 protein tyrosine kinase activity -0.024764
15 COG0149 triose-phosphate isomerase activity -0.024094
16 COG1272 protein, Hemolysin III -0.023770
17 COG0207 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis -0.023550
18 COG0389 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII -0.023379
19 COG3973 AAA domain -0.023209
20 COG0782 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus -0.023150
21 COG4106 trans-aconitate 2-methyltransferase activity -0.023053
22 COG0532 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex -0.023014
23 COG1353 crispr-associated protein 0.022973
24 COG2046 Belongs to the sulfate adenylyltransferase family 0.022787
25 COG0013 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain -0.022417
26 COG0594 ribonuclease P activity -0.022080
27 COG0148 phosphopyruvate hydratase activity -0.021958
28 COG0488 (ABC) transporter -0.021835
29 COG0270 DNA (cytosine-5-)-methyltransferase activity -0.021758
30 COG0558 Belongs to the CDP-alcohol phosphatidyltransferase class-I family -0.021606
31 COG1733 regulation of RNA biosynthetic process -0.021474
32 COG1974 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair -0.021330
33 COG2964 Protein conserved in bacteria -0.021306
34 COG4572 Cation transport regulator 0.021125
35 COG1704 LemA family -0.021006
36 COG0537 adenosine 5'-monophosphoramidase activity -0.020904
37 COG1547 Domain of unknown function (DUF309) 0.020876
38 COG0342 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA -0.020794
39 COG4942 peptidase -0.020757
40 COG3344 reverse transcriptase -0.020668
41 COG0326 Molecular chaperone. Has ATPase activity -0.020607
42 COG1517 CRISPR-associated protein, TM1812 family 0.020400
43 COG1301 dicarboxylic acid transport -0.020379
44 COG3462 membrane protein (DUF2078) 0.020302
45 COG0194 GDP metabolic process -0.020233
46 COG1993 acr, cog1993 0.020212
47 COG1961 COG1961 Site-specific recombinases, DNA invertase Pin homologs -0.019950
48 COG2018 Roadblock/LC7 domain 0.019917
49 COG0514 ATP-dependent DNA helicase (RecQ) -0.019782
50 COG1054 Belongs to the UPF0176 family -0.019764
51 COG1647 Serine aminopeptidase, S33 -0.019727
52 COG1180 Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine 0.019612
53 COG3221 ABC-type phosphate phosphonate transport system periplasmic component -0.019568
54 COG2274 protein secretion by the type I secretion system -0.019429
55 COG3270 Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA 0.019422
56 COG1190 Belongs to the class-II aminoacyl-tRNA synthetase family -0.019337
57 COG2378 regulation of single-species biofilm formation -0.019221
58 COG2154 pterin-4-alpha-carbinolamine dehydratase 0.019196
59 COG1721 protein (some members contain a von Willebrand factor type A (vWA) domain 0.019136
60 COG0466 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner -0.019012
61 COG0716 FMN binding -0.018960
62 COG0017 Asparaginyl-tRNA synthetase -0.018903
63 COG0370 Transporter of a GTP-driven Fe(2 ) uptake system 0.018892
64 COG2723 6-phospho-beta-galactosidase activity 0.018878
65 COG1832 CoA-binding protein 0.018847
66 COG1428 Deoxynucleoside kinase -0.018846
67 COG5377 YqaJ viral recombinase family -0.018760
68 COG4627 Pfam Methyltransferase -0.018739
69 COG1857 crispr-associated protein 0.018730
70 COG0756 dUTP diphosphatase activity -0.018599
71 COG1367 TIGRFAM CRISPR-associated RAMP protein, Cmr1 family 0.018595
72 COG1924 4 iron, 4 sulfur cluster binding -0.018420
73 COG2152 Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose 0.018400
74 COG3387 PFAM Glycoside hydrolase 15-related 0.018378
75 COG1553 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE 0.018339
76 COG1801 Protein of unknown function DUF72 0.018225
77 COG3711 transcriptional antiterminator -0.018201
78 COG1074 ATP-dependent DNA helicase activity -0.018172
79 COG1253 flavin adenine dinucleotide binding -0.018164
80 COG1129 ABC transporter 0.018162
81 COG1331 Highly conserved protein containing a thioredoxin domain 0.018148
82 COG2105 PFAM AIG2 family protein 0.018109
83 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain -0.018083
84 COG0308 aminopeptidase N -0.017956
85 COG3212 peptidase 0.017938
86 COG2840 Smr protein MutS2 -0.017878
87 COG2240 Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP -0.017825
88 COG1934 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm -0.017798
89 COG3638 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system -0.017744
90 COG2314 TM2 domain -0.017695
91 COG0760 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation -0.017683
92 COG0677 UDP-N-acetyl-D-mannosamine dehydrogenase activity 0.017677
93 COG0586 Pfam SNARE associated Golgi protein -0.017669
94 COG1434 Gram-negative-bacterium-type cell wall biogenesis 0.017607
95 COG1336 Crispr-associated ramp protein, Cmr4 family 0.017562
96 COG0605 Destroys radicals which are normally produced within the cells and which are toxic to biological systems -0.017540
97 COG1619 proteins homologs of microcin C7 resistance protein MccF -0.017463
98 COG3031 protein transport across the cell outer membrane 0.017461
99 33BH1 0.017351
100 COG0266 class I DNA-(apurinic or apyrimidinic site) endonuclease activity -0.017331
101 COG1355 regulation of microtubule-based process 0.017320
102 COG0260 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides -0.017291
103 COG1769 CRISPR-associated protein (Cas_Cmr3) 0.017285
104 COG1328 CTP reductase activity 0.017159
105 COG4105 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane -0.017078
106 COG2524 Domain in cystathionine beta-synthase and other proteins. 0.016951
107 COG1235 May be involved in the transport of PQQ or its precursor to the periplasm -0.016945
108 COG2254 TIGRFAM CRISPR-associated helicase Cas3 0.016491
109 COG2344 Modulates transcription in response to changes in cellular NADH NAD( ) redox state 0.016473
110 COG1122 ATPase activity -0.016437
111 COG1683 Conserved Protein 0.016380
112 COG2153 protein acetylation -0.016328
113 COG1774 PSP1 C-terminal conserved region 0.016308
114 COG3668 Plasmid stabilization system -0.016167
115 COG3337 CRISPR-associated protein (Cas_Cmr5) 0.016062
116 COG0591 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family -0.016057
117 COG0775 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively -0.016040
118 COG1335 isochorismatase 0.016023
119 COG2223 nitrite transmembrane transporter activity -0.016018
120 COG1076 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA -0.016001
121 COG4268 DNA restriction-modification system -0.015980
122 COG1183 phosphatidylcholine synthase activity -0.015939
123 COG1230 cation diffusion facilitator family transporter 0.015918
124 COG3883 PFAM NLP P60 protein 0.015908
125 COG3639 organic phosphonate transmembrane transporter activity -0.015873
126 COG0327 Belongs to the GTP cyclohydrolase I type 2 NIF3 family -0.015733
127 COG1238 metal cluster binding -0.015725
128 COG0714 Associated with various cellular activities 0.015712
129 COG1669 hydrolase activity, acting on ester bonds 0.015700
130 COG2151 metal-sulfur cluster biosynthetic enzyme 0.015680
131 COG2771 luxR family -0.015567
132 COG0696 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate -0.015511
133 COG3937 granule-associated protein 0.015496
134 COG1454 alcohol dehydrogenase 0.015482
135 COG0560 Phosphoserine phosphatase -0.015439
136 COG3087 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides -0.015347
137 COG0398 Pfam SNARE associated Golgi protein -0.015332
138 COG1794 racemase activity, acting on amino acids and derivatives -0.015331
139 COG0153 Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) 0.015317
140 COG2308 Evidence 4 Homologs of previously reported genes of -0.015274
141 2ZESX 0.015273
142 COG1943 Transposase 0.015266
143 COG3474 cytochrome 0.015257
144 COG1609 Transcriptional regulator 0.015236
145 COG1330 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity -0.015208
146 COG4823 Abi-like protein -0.015199
147 COG4753 response regulator -0.015141
148 COG1811 Na channel or pump 0.015132
149 COG4637 Psort location Cytoplasmic, score -0.015091
150 COG0688 phosphatidylethanolamine metabolic process -0.015074
151 COG2239 Acts as a magnesium transporter -0.015016
152 COG2041 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide 0.014993
153 COG2350 Protein conserved in bacteria -0.014982
154 COG1598 PFAM Uncharacterised protein family UPF0150 -0.014962
155 COG0639 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP -0.014935
156 COG0448 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans -0.014917
157 COG2867 negative regulation of translational initiation -0.014876
158 COG1564 THIamine pyrophosphokinase 0.014874
159 COG2391 methyltransferase activity 0.014857
160 COG3525 Glycosyl hydrolase, family 20, catalytic domain 0.014813
161 32YVX Protein of unknown function (DUF2905) 0.014775
162 COG0387 Pfam Sodium calcium exchanger 0.014746
163 COG0802 atpase or kinase -0.014722
164 COG3440 Restriction endonuclease -0.014717
165 COG1476 TRANSCRIPTIONal -0.014716
166 COG3749 Protein conserved in bacteria 0.014689
167 3373B 0.014649
168 COG0425 Belongs to the sulfur carrier protein TusA family 0.014636
169 COG1796 DNA polymerase 0.014491
170 COG3576 pyridoxamine 5-phosphate -0.014485
171 345M7 C4-type zinc ribbon domain -0.014476
172 COG0794 Belongs to the SIS family. GutQ KpsF subfamily -0.014470
173 COG2358 TRAP transporter, solute receptor (TAXI family -0.014458
174 COG3113 response to antibiotic 0.014409
175 COG2945 thiolester hydrolase activity 0.014398
176 COG1293 RNA-binding protein homologous to eukaryotic snRNP 0.014362
177 COG0627 Serine hydrolase involved in the detoxification of formaldehyde -0.014358
178 COG1332 CRISPR-associated RAMP protein, Csm5 family 0.014349
179 COG1604 cell adhesion 0.014337
180 COG0362 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH -0.014328
181 COG2456 Psort location CytoplasmicMembrane, score 0.014264
182 COG2045 Belongs to the ComB family 0.014261
183 COG4214 carbohydrate transport 0.014229
184 COG1741 Belongs to the pirin family -0.014220
185 COG1959 2 iron, 2 sulfur cluster binding 0.014218
186 COG3381 protein complex oligomerization 0.014203
187 COG0572 uridine kinase -0.014170
188 COG5360 Heparinase II/III-like protein -0.014139
189 COG3448 diguanylate cyclase activity -0.014084
190 COG4147 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family 0.014056
191 COG0698 ribose 5-phosphate isomerase -0.014050
192 COG2310 stress, protein -0.014038
193 COG1321 iron dependent repressor 0.014023
194 COG4916 TIR domain 0.014005
195 COG1530 ribonuclease E activity -0.013957
196 COG4175 Glycine betaine -0.013890
197 COG4176 ABC-type proline glycine betaine transport system permease component -0.013890
198 COG0386 Belongs to the glutathione peroxidase family -0.013854
199 COG1846 Transcriptional regulator -0.013844
200 COG1085 galactose-1-phosphate uridylyltransferase 0.013827
201 COG2359 stage V sporulation protein S 0.013817
202 COG0046 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL 0.013801
203 COG1928 C-terminal four TMM region of protein-O-mannosyltransferase 0.013800
204 COG0236 Carrier of the growing fatty acid chain in fatty acid biosynthesis 0.013771
205 COG1878 Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation 0.013752
206 COG4766 ethanolamine catabolic process -0.013706
207 COG0421 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine 0.013693
208 COG2177 Part of the ABC transporter FtsEX involved in 0.013658
209 COG3636 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD -0.013656
210 COG4174 ABC transporter (Permease) -0.013648
211 COG1566 PFAM secretion protein HlyD family protein -0.013628
212 COG5184 regulator of chromosome condensation, RCC1 0.013608
213 COG0300 oxidoreductase activity -0.013605
214 COG1038 Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second -0.013596
215 COG4006 CRISPR-associated protein, APE2256 family 0.013590
216 COG4115 mRNA cleavage -0.013571
217 COG4232 protein-disulfide reductase activity -0.013568
218 COG3041 Addiction module toxin RelE StbE family -0.013512
219 COG2313 pseudouridylate synthase activity 0.013508
220 COG0229 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine -0.013498
221 COG2021 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine 0.013496
222 COG2963 transposase activity -0.013491
223 COG1421 Csm2 Type III-A 0.013485
224 COG5438 YibE/F-like protein -0.013483
225 COG0391 Required for morphogenesis under gluconeogenic growth conditions 0.013439
226 COG1337 RAMP superfamily 0.013433
227 COG2827 Endonuclease containing a URI domain -0.013415
228 COG1748 Saccharopine dehydrogenase -0.013346
229 COG5350 Protein tyrosine phosphatase -0.013272
230 COG2382 esterase 0.013271
231 COG3208 Thioesterase involved in non-ribosomal peptide biosynthesis -0.013270
232 COG4181 ATPase activity -0.013209
233 COG4585 Histidine kinase -0.013202
234 COG2072 flavoprotein involved in K transport -0.013167
235 COG1164 Oligoendopeptidase f -0.013148
236 31MD8 Cysteine-rich secretory protein family 0.013114
237 COG0550 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone -0.013102
238 COG1567 CRISPR-associated RAMP protein, Csm4 family 0.013069
239 COG1144 Oxidoreductase 0.013020
240 2ZCN4 0.013007
241 COG3396 Phenylacetate-CoA oxygenase 0.012986
242 COG3848 Pyruvate phosphate dikinase -0.012952
243 COG0584 glycerophosphoryl diester phosphodiesterase -0.012906
244 COG0341 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA -0.012884
245 COG0599 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity 0.012852
246 COG1217 gtp-binding protein TYPA -0.012831
247 COG3757 hydrolase, family 25 -0.012816
248 COG2320 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A -0.012812
249 COG3797 Protein conserved in bacteria -0.012811
250 COG2271 Major facilitator Superfamily -0.012808