Model Internals
Each PhenDB model is trained on sets of bacterial ENOGs (orthologous groups from EggNOG 4.5), which have or have not been identified in the training genomes. Each ENOG is given a weight, with the magnitude of the weight being the importance of that ENOG for the final prediction. The sign of the weight indicates whether the presence (positive weight) or absence (negative weight) of this ENOG is indicative of the trait.
This table lists the 250 highest-ranking ENOGs of this model.
rank in model | enog name | enog description | weight in model |
---|---|---|---|
1 | COG0568 | sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released | -0.036631 |
2 | COG0513 | Belongs to the DEAD box helicase family | -0.033416 |
3 | COG0736 | holo-[acyl-carrier-protein] synthase activity | -0.030954 |
4 | COG0358 | DNA primase activity | -0.029102 |
5 | COG2110 | phosphatase homologous to the C-terminal domain of histone macroH2A1 | 0.028434 |
6 | COG4591 | ABC-type transport system involved in lipoprotein release permease component | -0.028074 |
7 | COG1514 | Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester | 0.027763 |
8 | COG3591 | Belongs to the peptidase S1B family | -0.027166 |
9 | COG2249 | NAD(P)H dehydrogenase (quinone) activity | -0.025754 |
10 | COG0571 | ribonuclease III activity | -0.025418 |
11 | COG0230 | Belongs to the bacterial ribosomal protein bL34 family | -0.025071 |
12 | COG0262 | Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | -0.024929 |
13 | COG0692 | Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine | -0.024894 |
14 | COG0489 | protein tyrosine kinase activity | -0.024764 |
15 | COG0149 | triose-phosphate isomerase activity | -0.024094 |
16 | COG1272 | protein, Hemolysin III | -0.023770 |
17 | COG0207 | Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis | -0.023550 |
18 | COG0389 | Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII | -0.023379 |
19 | COG3973 | AAA domain | -0.023209 |
20 | COG0782 | Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus | -0.023150 |
21 | COG4106 | trans-aconitate 2-methyltransferase activity | -0.023053 |
22 | COG0532 | One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex | -0.023014 |
23 | COG1353 | crispr-associated protein | 0.022973 |
24 | COG2046 | Belongs to the sulfate adenylyltransferase family | 0.022787 |
25 | COG0013 | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain | -0.022417 |
26 | COG0594 | ribonuclease P activity | -0.022080 |
27 | COG0148 | phosphopyruvate hydratase activity | -0.021958 |
28 | COG0488 | (ABC) transporter | -0.021835 |
29 | COG0270 | DNA (cytosine-5-)-methyltransferase activity | -0.021758 |
30 | COG0558 | Belongs to the CDP-alcohol phosphatidyltransferase class-I family | -0.021606 |
31 | COG1733 | regulation of RNA biosynthetic process | -0.021474 |
32 | COG1974 | Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair | -0.021330 |
33 | COG2964 | Protein conserved in bacteria | -0.021306 |
34 | COG4572 | Cation transport regulator | 0.021125 |
35 | COG1704 | LemA family | -0.021006 |
36 | COG0537 | adenosine 5'-monophosphoramidase activity | -0.020904 |
37 | COG1547 | Domain of unknown function (DUF309) | 0.020876 |
38 | COG0342 | Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA | -0.020794 |
39 | COG4942 | peptidase | -0.020757 |
40 | COG3344 | reverse transcriptase | -0.020668 |
41 | COG0326 | Molecular chaperone. Has ATPase activity | -0.020607 |
42 | COG1517 | CRISPR-associated protein, TM1812 family | 0.020400 |
43 | COG1301 | dicarboxylic acid transport | -0.020379 |
44 | COG3462 | membrane protein (DUF2078) | 0.020302 |
45 | COG0194 | GDP metabolic process | -0.020233 |
46 | COG1993 | acr, cog1993 | 0.020212 |
47 | COG1961 | COG1961 Site-specific recombinases, DNA invertase Pin homologs | -0.019950 |
48 | COG2018 | Roadblock/LC7 domain | 0.019917 |
49 | COG0514 | ATP-dependent DNA helicase (RecQ) | -0.019782 |
50 | COG1054 | Belongs to the UPF0176 family | -0.019764 |
51 | COG1647 | Serine aminopeptidase, S33 | -0.019727 |
52 | COG1180 | Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine | 0.019612 |
53 | COG3221 | ABC-type phosphate phosphonate transport system periplasmic component | -0.019568 |
54 | COG2274 | protein secretion by the type I secretion system | -0.019429 |
55 | COG3270 | Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA | 0.019422 |
56 | COG1190 | Belongs to the class-II aminoacyl-tRNA synthetase family | -0.019337 |
57 | COG2378 | regulation of single-species biofilm formation | -0.019221 |
58 | COG2154 | pterin-4-alpha-carbinolamine dehydratase | 0.019196 |
59 | COG1721 | protein (some members contain a von Willebrand factor type A (vWA) domain | 0.019136 |
60 | COG0466 | ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner | -0.019012 |
61 | COG0716 | FMN binding | -0.018960 |
62 | COG0017 | Asparaginyl-tRNA synthetase | -0.018903 |
63 | COG0370 | Transporter of a GTP-driven Fe(2 ) uptake system | 0.018892 |
64 | COG2723 | 6-phospho-beta-galactosidase activity | 0.018878 |
65 | COG1832 | CoA-binding protein | 0.018847 |
66 | COG1428 | Deoxynucleoside kinase | -0.018846 |
67 | COG5377 | YqaJ viral recombinase family | -0.018760 |
68 | COG4627 | Pfam Methyltransferase | -0.018739 |
69 | COG1857 | crispr-associated protein | 0.018730 |
70 | COG0756 | dUTP diphosphatase activity | -0.018599 |
71 | COG1367 | TIGRFAM CRISPR-associated RAMP protein, Cmr1 family | 0.018595 |
72 | COG1924 | 4 iron, 4 sulfur cluster binding | -0.018420 |
73 | COG2152 | Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose | 0.018400 |
74 | COG3387 | PFAM Glycoside hydrolase 15-related | 0.018378 |
75 | COG1553 | Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE | 0.018339 |
76 | COG1801 | Protein of unknown function DUF72 | 0.018225 |
77 | COG3711 | transcriptional antiterminator | -0.018201 |
78 | COG1074 | ATP-dependent DNA helicase activity | -0.018172 |
79 | COG1253 | flavin adenine dinucleotide binding | -0.018164 |
80 | COG1129 | ABC transporter | 0.018162 |
81 | COG1331 | Highly conserved protein containing a thioredoxin domain | 0.018148 |
82 | COG2105 | PFAM AIG2 family protein | 0.018109 |
83 | COG0834 | ABC-type amino acid transport signal transduction systems periplasmic component domain | -0.018083 |
84 | COG0308 | aminopeptidase N | -0.017956 |
85 | COG3212 | peptidase | 0.017938 |
86 | COG2840 | Smr protein MutS2 | -0.017878 |
87 | COG2240 | Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP | -0.017825 |
88 | COG1934 | Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm | -0.017798 |
89 | COG3638 | Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system | -0.017744 |
90 | COG2314 | TM2 domain | -0.017695 |
91 | COG0760 | Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation | -0.017683 |
92 | COG0677 | UDP-N-acetyl-D-mannosamine dehydrogenase activity | 0.017677 |
93 | COG0586 | Pfam SNARE associated Golgi protein | -0.017669 |
94 | COG1434 | Gram-negative-bacterium-type cell wall biogenesis | 0.017607 |
95 | COG1336 | Crispr-associated ramp protein, Cmr4 family | 0.017562 |
96 | COG0605 | Destroys radicals which are normally produced within the cells and which are toxic to biological systems | -0.017540 |
97 | COG1619 | proteins homologs of microcin C7 resistance protein MccF | -0.017463 |
98 | COG3031 | protein transport across the cell outer membrane | 0.017461 |
99 | 33BH1 | 0.017351 | |
100 | COG0266 | class I DNA-(apurinic or apyrimidinic site) endonuclease activity | -0.017331 |
101 | COG1355 | regulation of microtubule-based process | 0.017320 |
102 | COG0260 | Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides | -0.017291 |
103 | COG1769 | CRISPR-associated protein (Cas_Cmr3) | 0.017285 |
104 | COG1328 | CTP reductase activity | 0.017159 |
105 | COG4105 | Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane | -0.017078 |
106 | COG2524 | Domain in cystathionine beta-synthase and other proteins. | 0.016951 |
107 | COG1235 | May be involved in the transport of PQQ or its precursor to the periplasm | -0.016945 |
108 | COG2254 | TIGRFAM CRISPR-associated helicase Cas3 | 0.016491 |
109 | COG2344 | Modulates transcription in response to changes in cellular NADH NAD( ) redox state | 0.016473 |
110 | COG1122 | ATPase activity | -0.016437 |
111 | COG1683 | Conserved Protein | 0.016380 |
112 | COG2153 | protein acetylation | -0.016328 |
113 | COG1774 | PSP1 C-terminal conserved region | 0.016308 |
114 | COG3668 | Plasmid stabilization system | -0.016167 |
115 | COG3337 | CRISPR-associated protein (Cas_Cmr5) | 0.016062 |
116 | COG0591 | Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family | -0.016057 |
117 | COG0775 | Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively | -0.016040 |
118 | COG1335 | isochorismatase | 0.016023 |
119 | COG2223 | nitrite transmembrane transporter activity | -0.016018 |
120 | COG1076 | Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA | -0.016001 |
121 | COG4268 | DNA restriction-modification system | -0.015980 |
122 | COG1183 | phosphatidylcholine synthase activity | -0.015939 |
123 | COG1230 | cation diffusion facilitator family transporter | 0.015918 |
124 | COG3883 | PFAM NLP P60 protein | 0.015908 |
125 | COG3639 | organic phosphonate transmembrane transporter activity | -0.015873 |
126 | COG0327 | Belongs to the GTP cyclohydrolase I type 2 NIF3 family | -0.015733 |
127 | COG1238 | metal cluster binding | -0.015725 |
128 | COG0714 | Associated with various cellular activities | 0.015712 |
129 | COG1669 | hydrolase activity, acting on ester bonds | 0.015700 |
130 | COG2151 | metal-sulfur cluster biosynthetic enzyme | 0.015680 |
131 | COG2771 | luxR family | -0.015567 |
132 | COG0696 | Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate | -0.015511 |
133 | COG3937 | granule-associated protein | 0.015496 |
134 | COG1454 | alcohol dehydrogenase | 0.015482 |
135 | COG0560 | Phosphoserine phosphatase | -0.015439 |
136 | COG3087 | Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides | -0.015347 |
137 | COG0398 | Pfam SNARE associated Golgi protein | -0.015332 |
138 | COG1794 | racemase activity, acting on amino acids and derivatives | -0.015331 |
139 | COG0153 | Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) | 0.015317 |
140 | COG2308 | Evidence 4 Homologs of previously reported genes of | -0.015274 |
141 | 2ZESX | 0.015273 | |
142 | COG1943 | Transposase | 0.015266 |
143 | COG3474 | cytochrome | 0.015257 |
144 | COG1609 | Transcriptional regulator | 0.015236 |
145 | COG1330 | A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity | -0.015208 |
146 | COG4823 | Abi-like protein | -0.015199 |
147 | COG4753 | response regulator | -0.015141 |
148 | COG1811 | Na channel or pump | 0.015132 |
149 | COG4637 | Psort location Cytoplasmic, score | -0.015091 |
150 | COG0688 | phosphatidylethanolamine metabolic process | -0.015074 |
151 | COG2239 | Acts as a magnesium transporter | -0.015016 |
152 | COG2041 | Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide | 0.014993 |
153 | COG2350 | Protein conserved in bacteria | -0.014982 |
154 | COG1598 | PFAM Uncharacterised protein family UPF0150 | -0.014962 |
155 | COG0639 | Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP | -0.014935 |
156 | COG0448 | Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans | -0.014917 |
157 | COG2867 | negative regulation of translational initiation | -0.014876 |
158 | COG1564 | THIamine pyrophosphokinase | 0.014874 |
159 | COG2391 | methyltransferase activity | 0.014857 |
160 | COG3525 | Glycosyl hydrolase, family 20, catalytic domain | 0.014813 |
161 | 32YVX | Protein of unknown function (DUF2905) | 0.014775 |
162 | COG0387 | Pfam Sodium calcium exchanger | 0.014746 |
163 | COG0802 | atpase or kinase | -0.014722 |
164 | COG3440 | Restriction endonuclease | -0.014717 |
165 | COG1476 | TRANSCRIPTIONal | -0.014716 |
166 | COG3749 | Protein conserved in bacteria | 0.014689 |
167 | 3373B | 0.014649 | |
168 | COG0425 | Belongs to the sulfur carrier protein TusA family | 0.014636 |
169 | COG1796 | DNA polymerase | 0.014491 |
170 | COG3576 | pyridoxamine 5-phosphate | -0.014485 |
171 | 345M7 | C4-type zinc ribbon domain | -0.014476 |
172 | COG0794 | Belongs to the SIS family. GutQ KpsF subfamily | -0.014470 |
173 | COG2358 | TRAP transporter, solute receptor (TAXI family | -0.014458 |
174 | COG3113 | response to antibiotic | 0.014409 |
175 | COG2945 | thiolester hydrolase activity | 0.014398 |
176 | COG1293 | RNA-binding protein homologous to eukaryotic snRNP | 0.014362 |
177 | COG0627 | Serine hydrolase involved in the detoxification of formaldehyde | -0.014358 |
178 | COG1332 | CRISPR-associated RAMP protein, Csm5 family | 0.014349 |
179 | COG1604 | cell adhesion | 0.014337 |
180 | COG0362 | Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH | -0.014328 |
181 | COG2456 | Psort location CytoplasmicMembrane, score | 0.014264 |
182 | COG2045 | Belongs to the ComB family | 0.014261 |
183 | COG4214 | carbohydrate transport | 0.014229 |
184 | COG1741 | Belongs to the pirin family | -0.014220 |
185 | COG1959 | 2 iron, 2 sulfur cluster binding | 0.014218 |
186 | COG3381 | protein complex oligomerization | 0.014203 |
187 | COG0572 | uridine kinase | -0.014170 |
188 | COG5360 | Heparinase II/III-like protein | -0.014139 |
189 | COG3448 | diguanylate cyclase activity | -0.014084 |
190 | COG4147 | Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family | 0.014056 |
191 | COG0698 | ribose 5-phosphate isomerase | -0.014050 |
192 | COG2310 | stress, protein | -0.014038 |
193 | COG1321 | iron dependent repressor | 0.014023 |
194 | COG4916 | TIR domain | 0.014005 |
195 | COG1530 | ribonuclease E activity | -0.013957 |
196 | COG4175 | Glycine betaine | -0.013890 |
197 | COG4176 | ABC-type proline glycine betaine transport system permease component | -0.013890 |
198 | COG0386 | Belongs to the glutathione peroxidase family | -0.013854 |
199 | COG1846 | Transcriptional regulator | -0.013844 |
200 | COG1085 | galactose-1-phosphate uridylyltransferase | 0.013827 |
201 | COG2359 | stage V sporulation protein S | 0.013817 |
202 | COG0046 | Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL | 0.013801 |
203 | COG1928 | C-terminal four TMM region of protein-O-mannosyltransferase | 0.013800 |
204 | COG0236 | Carrier of the growing fatty acid chain in fatty acid biosynthesis | 0.013771 |
205 | COG1878 | Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation | 0.013752 |
206 | COG4766 | ethanolamine catabolic process | -0.013706 |
207 | COG0421 | Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine | 0.013693 |
208 | COG2177 | Part of the ABC transporter FtsEX involved in | 0.013658 |
209 | COG3636 | A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD | -0.013656 |
210 | COG4174 | ABC transporter (Permease) | -0.013648 |
211 | COG1566 | PFAM secretion protein HlyD family protein | -0.013628 |
212 | COG5184 | regulator of chromosome condensation, RCC1 | 0.013608 |
213 | COG0300 | oxidoreductase activity | -0.013605 |
214 | COG1038 | Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second | -0.013596 |
215 | COG4006 | CRISPR-associated protein, APE2256 family | 0.013590 |
216 | COG4115 | mRNA cleavage | -0.013571 |
217 | COG4232 | protein-disulfide reductase activity | -0.013568 |
218 | COG3041 | Addiction module toxin RelE StbE family | -0.013512 |
219 | COG2313 | pseudouridylate synthase activity | 0.013508 |
220 | COG0229 | Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine | -0.013498 |
221 | COG2021 | Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine | 0.013496 |
222 | COG2963 | transposase activity | -0.013491 |
223 | COG1421 | Csm2 Type III-A | 0.013485 |
224 | COG5438 | YibE/F-like protein | -0.013483 |
225 | COG0391 | Required for morphogenesis under gluconeogenic growth conditions | 0.013439 |
226 | COG1337 | RAMP superfamily | 0.013433 |
227 | COG2827 | Endonuclease containing a URI domain | -0.013415 |
228 | COG1748 | Saccharopine dehydrogenase | -0.013346 |
229 | COG5350 | Protein tyrosine phosphatase | -0.013272 |
230 | COG2382 | esterase | 0.013271 |
231 | COG3208 | Thioesterase involved in non-ribosomal peptide biosynthesis | -0.013270 |
232 | COG4181 | ATPase activity | -0.013209 |
233 | COG4585 | Histidine kinase | -0.013202 |
234 | COG2072 | flavoprotein involved in K transport | -0.013167 |
235 | COG1164 | Oligoendopeptidase f | -0.013148 |
236 | 31MD8 | Cysteine-rich secretory protein family | 0.013114 |
237 | COG0550 | Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone | -0.013102 |
238 | COG1567 | CRISPR-associated RAMP protein, Csm4 family | 0.013069 |
239 | COG1144 | Oxidoreductase | 0.013020 |
240 | 2ZCN4 | 0.013007 | |
241 | COG3396 | Phenylacetate-CoA oxygenase | 0.012986 |
242 | COG3848 | Pyruvate phosphate dikinase | -0.012952 |
243 | COG0584 | glycerophosphoryl diester phosphodiesterase | -0.012906 |
244 | COG0341 | Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA | -0.012884 |
245 | COG0599 | Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity | 0.012852 |
246 | COG1217 | gtp-binding protein TYPA | -0.012831 |
247 | COG3757 | hydrolase, family 25 | -0.012816 |
248 | COG2320 | Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A | -0.012812 |
249 | COG3797 | Protein conserved in bacteria | -0.012811 |
250 | COG2271 | Major facilitator Superfamily | -0.012808 |