Metamenu

Model Internals

Each PhenDB model is trained on sets of bacterial ENOGs (orthologous groups from EggNOG 4.5), which have or have not been identified in the training genomes. Each ENOG is given a weight, with the magnitude of the weight being the importance of that ENOG for the final prediction. The sign of the weight indicates whether the presence (positive weight) or absence (negative weight) of this ENOG is indicative of the trait.

This table lists the 250 highest-ranking ENOGs of this model.

rank in model enog name enog description weight in model
1 COG0227 Belongs to the bacterial ribosomal protein bL28 family -0.016630
2 COG0292 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit -0.016630
3 COG0211 Belongs to the bacterial ribosomal protein bL27 family -0.016557
4 COG0050 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis -0.016496
5 COG0228 four-way junction DNA binding -0.016496
6 COG0568 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released -0.016391
7 COG0482 sulfurtransferase activity -0.016102
8 COG0202 RNA polymerase activity -0.016037
9 COG0257 Belongs to the bacterial ribosomal protein bL36 family -0.015876
10 COG0587 DNA-directed DNA polymerase activity -0.015835
11 COG0333 Belongs to the bacterial ribosomal protein bL32 family -0.015694
12 COG0216 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA -0.015100
13 COG0234 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter -0.015043
14 COG0233 cytoplasmic translational termination -0.014844
15 COG0445 tRNA wobble uridine modification -0.014791
16 COG0264 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome -0.014603
17 COG0564 pseudouridine synthase activity -0.014591
18 COG0290 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins -0.014573
19 COG0740 serine-type endopeptidase activity -0.014360
20 COG0254 rRNA binding -0.013642
21 COG0691 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene -0.013642
22 COG0261 This protein binds to 23S rRNA in the presence of protein L20 -0.013623
23 COG0275 rRNA processing -0.013415
24 COG0305 Participates in initiation and elongation during chromosome replication -0.013129
25 COG0267 Belongs to the bacterial ribosomal protein bL33 family -0.012957
26 COG0222 ribosome binding -0.012694
27 COG0242 peptide deformylase activity -0.012625
28 COG0203 ribosomal protein L17 -0.012588
29 COG0335 large ribosomal subunit rRNA binding -0.012348
30 COG0238 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit -0.012305
31 COG0291 Belongs to the bacterial ribosomal protein bL35 family -0.012160
32 COG0199 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site -0.011874
33 COG0173 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) -0.011457
34 COG0566 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family -0.011241
35 COG0358 DNA primase activity -0.011139
36 COG0361 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex -0.010849
37 COG0162 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) -0.010836
38 COG1219 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP -0.010821
39 COG0847 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease -0.010774
40 COG0197 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs -0.010612
41 COG0468 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage -0.010571
42 COG0356 it plays a direct role in the translocation of protons across the membrane -0.010518
43 COG0055 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits -0.010385
44 COG0056 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit -0.010385
45 COG0224 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex -0.010314
46 COG0355 proton-transporting ATP synthase activity, rotational mechanism -0.010181
47 COG1825 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance -0.010080
48 COG0782 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus -0.009973
49 COG0752 glycyl-tRNA synthetase alpha subunit -0.009835
50 COG0443 Heat shock 70 kDa protein -0.009811
51 COG1867 N(2),N(2)-dimethylguanosine tRNA methyltransferase 0.009703
52 COG1163 TGS domain 0.009647
53 COG0486 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 -0.009552
54 COG1389 DNA topoisomerase II activity 0.009521
55 COG1990 Peptidyl-tRNA hydrolase 0.009489
56 COG1186 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA -0.009479
57 COG0268 Binds directly to 16S ribosomal RNA -0.009356
58 COG1697 DNA topoisomerase VI subunit A 0.009281
59 COG1718 Serine threonine protein kinase involved in cell cycle control 0.009242
60 COG2102 of PP-loop superfamily 0.009202
61 COG1658 Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step 0.009161
62 COG0685 methylenetetrahydrofolate reductase (NAD(P)H) activity -0.009154
63 COG0360 Binds together with S18 to 16S ribosomal RNA -0.009096
64 COG0638 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine 0.009062
65 COG0585 pseudouridine synthase activity 0.009060
66 COG0417 DNA replication proofreading 0.009004
67 COG0629 single-stranded DNA binding -0.009000
68 COG0337 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) -0.008915
69 COG1358 cellular component organization or biogenesis 0.008876
70 COG1378 Sugar-specific transcriptional regulator TrmB 0.008752
71 COG1407 ICC-like phosphoesterases 0.008743
72 COG0184 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome -0.008739
73 COG1899 peptidyl-lysine modification to peptidyl-hypusine 0.008697
74 COG1155 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit 0.008544
75 COG0088 Forms part of the polypeptide exit tunnel -0.008532
76 COG3276 selenocysteine insertion sequence binding 0.008528
77 COG1156 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit 0.008389
78 COG0630 type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis 0.008383
79 COG2511 GatB/GatE catalytic domain 0.008350
80 COG0023 Translation Initiation Factor 0.008269
81 COG1394 ATPase activity, coupled to movement of substances 0.008263
82 COG1371 PFAM Archease protein family (DUF101 UPF0211) 0.008231
83 COG2895 sulfate adenylyltransferase (ATP) activity 0.008219
84 COG1468 defense response to virus 0.008167
85 COG0757 Catalyzes a trans-dehydration via an enolate intermediate -0.008039
86 COG0576 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ -0.008034
87 COG1269 ATP hydrolysis coupled proton transport 0.008005
88 COG1591 pfam vrr-nuc 0.008002
89 COG0230 Belongs to the bacterial ribosomal protein bL34 family -0.007897
90 COG1098 S1 RNA binding domain 0.007888
91 COG2404 hydrolase activity, acting on ester bonds 0.007828
92 COG1746 tRNA cytidylyltransferase activity 0.007733
93 COG1047 Peptidyl-prolyl cis-trans 0.007663
94 COG0722 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) -0.007651
95 COG1384 Belongs to the class-I aminoacyl-tRNA synthetase family 0.007633
96 COG3677 Transposase 0.007617
97 COG0495 leucyl-tRNA aminoacylation -0.007548
98 COG0858 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA -0.007467
99 COG0170 dolichyl monophosphate biosynthetic process 0.007458
100 COG2064 Type II secretion system (T2SS), protein F 0.007377
101 COG0021 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate -0.007324
102 COG2908 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell 0.007303
103 COG0098 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body -0.007303
104 COG0301 tRNA thio-modification 0.007302
105 COG0176 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway -0.007279
106 COG0703 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate -0.007255
107 COG1503 nitronate monooxygenase activity 0.007225
108 COG1339 Domain of unknown function DUF120 0.007189
109 COG1201 RNA secondary structure unwinding 0.007184
110 COG1690 Belongs to the RtcB family 0.007170
111 COG0103 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) -0.007161
112 COG0539 negative regulation of cytoplasmic translation -0.007155
113 COG1234 tRNA 3'-trailer cleavage 0.007153
114 COG0252 asparaginase activity 0.007146
115 COG1244 Elongator protein 3, MiaB family, Radical SAM 0.007117
116 COG1549 archaeosine synthase activity 0.007117
117 COG2243 precorrin-2 c20-methyltransferase 0.007099
118 COG0094 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits -0.007084
119 COG0096 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit -0.007084
120 COG0092 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation -0.007084
121 COG0093 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome -0.007084
122 COG0102 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly -0.007084
123 COG0186 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA -0.007084
124 COG0480 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome -0.007084
125 COG0091 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome -0.007064
126 COG0097 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center -0.007064
127 COG0048 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit -0.007061
128 COG0099 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits -0.007056
129 COG1793 dna ligase 0.007049
130 COG2524 Domain in cystathionine beta-synthase and other proteins. 0.007036
131 COG0100 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome -0.007015
132 COG1646 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales 0.007010
133 COG1829 GHMP kinases N terminal domain 0.007004
134 COG0357 Ribosomal RNA small subunit methyltransferase G -0.006997
135 COG0051 transcription antitermination factor activity, RNA binding -0.006974
136 COG0049 tRNA binding -0.006970
137 COG0481 GTPase activity -0.006964
138 COG0010 Belongs to the arginase family 0.006952
139 COG0319 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA -0.006948
140 COG0185 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA -0.006926
141 COG1913 serine-type endopeptidase activity 0.006892
142 COG0080 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors -0.006890
143 COG0653 protein targeting -0.006871
144 COG1458 PINc domain ribonuclease 0.006869
145 COG0085 RNA polymerase activity -0.006841
146 COG2842 Transposition protein 0.006801
147 COG0090 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity -0.006778
148 COG1608 PFAM aspartate glutamate uridylate kinase 0.006772
149 COG0194 GDP metabolic process -0.006770
150 COG1848 Toxic component of a toxin-antitoxin (TA) module. An RNase 0.006765
151 COG0594 ribonuclease P activity -0.006743
152 COG0193 aminoacyl-tRNA hydrolase activity -0.006743
153 COG0532 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex -0.006729
154 COG1056 cytidyltransferase-related domain 0.006691
155 COG0706 membrane insertase activity -0.006689
156 COG1208 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon 0.006646
157 COG0362 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH -0.006590
158 COG1120 ATPase activity 0.006584
159 COG1781 'de novo' pyrimidine nucleobase biosynthetic process 0.006576
160 COG0781 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons -0.006565
161 COG1992 Thiamine-phosphate synthase 0.006542
162 COG1222 aaa ATPase 0.006529
163 COG0087 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit -0.006494
164 COG0522 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit -0.006494
165 COG0433 COG0433 Predicted ATPase 0.006493
166 COG2042 rRNA processing 0.006464
167 COG0462 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) -0.006434
168 COG3357 Transcriptional regulator containing an HTH domain fused to a Zn-ribbon 0.006432
169 COG1436 Produces ATP from ADP in the presence of a proton gradient across the membrane 0.006432
170 COG3886 PLD-like domain 0.006431
171 COG2411 cytidine deaminase activity 0.006429
172 2Z9ZP Conserved TM helix 0.006428
173 COG0799 negative regulation of ribosome biogenesis -0.006417
174 COG0476 Involved in molybdopterin and thiamine biosynthesis, family 2 0.006369
175 COG2888 peptidyl-tyrosine sulfation 0.006356
176 COG4962 Type ii secretion system protein e 0.006344
177 COG0710 3-dehydroquinate dehydratase activity 0.006337
178 COG4083 PFAM Transmembrane exosortase (Exosortase_EpsH) 0.006328
179 COG0359 binds to the 23S rRNA -0.006315
180 COG2171 N-acyltransferase activity -0.006298
181 COG1994 Peptidase M50 0.006294
182 COG2520 Methyltransferase fkbm family 0.006292
183 COG1650 D-aminoacyl-tRNA deacylase 0.006289
184 33CZD Helix-hairpin-helix domain 0.006271
185 COG0864 Transcriptional regulator 0.006270
186 COG1236 Exonuclease of the beta-lactamase fold involved in RNA processing 0.006249
187 COG3425 synthase 0.006245
188 COG1257 Belongs to the HMG-CoA reductase family 0.006231
189 COG0336 Belongs to the RNA methyltransferase TrmD family -0.006225
190 COG3474 cytochrome -0.006214
191 COG2090 Domain of unknown function (DUF371) 0.006209
192 COG0712 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation -0.006205
193 COG1405 negative regulation of cell septum assembly 0.006181
194 COG0200 Binds to the 23S rRNA -0.006177
195 COG1444 tRNA N-acetyltransferase activity 0.006168
196 COG0776 regulation of translation -0.006123
197 COG1527 subunit (C 0.006118
198 COG1522 sequence-specific DNA binding 0.006117
199 COG1693 Ribonuclease R winged-helix domain protein 0.006097
200 COG2019 rRNA binding 0.006092
201 COG0350 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated 0.006066
202 COG0593 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids -0.006060
203 COG0484 heat shock protein binding -0.006057
204 COG1712 Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate 0.006055
205 COG1948 resolution of meiotic recombination intermediates 0.006052
206 COG0536 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control -0.006047
207 COG1078 dGTPase activity 0.005962
208 COG1390 Produces ATP from ADP in the presence of a proton gradient across the membrane 0.005959
209 COG1525 nuclease 0.005953
210 337N0 0.005936
211 COG2872 Ser-tRNA(Ala) hydrolase activity 0.005914
212 COG3642 lipopolysaccharide core region biosynthetic process 0.005897
213 COG1204 response to ionizing radiation 0.005896
214 COG1102 Psort location Cytoplasmic, score 0.005895
215 COG0731 radical SAM domain protein 0.005891
216 COG1577 mevalonate kinase activity 0.005886
217 COG0828 Belongs to the bacterial ribosomal protein bS21 family -0.005886
218 COG1514 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester 0.005860
219 COG1243 radical SAM domain protein 0.005798
220 COG2087 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate -0.005798
221 COG1355 regulation of microtubule-based process 0.005785
222 COG0466 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner -0.005773
223 COG0658 competence protein -0.005768
224 COG1628 Protein of unknown function DUF99 0.005743
225 COG1465 3-dehydroquinate synthase 0.005727
226 COG0334 Belongs to the Glu Leu Phe Val dehydrogenases family 0.005725
227 COG0714 Associated with various cellular activities 0.005718
228 COG0205 6-phosphofructokinase activity -0.005669
229 COG1045 serine acetyltransferase -0.005652
230 COG0544 peptidyl-prolyl cis-trans isomerase activity -0.005643
231 COG0343 queuine tRNA-ribosyltransferase activity 0.005625
232 COG0420 3'-5' exonuclease activity 0.005622
233 COG1308 UBA TS-N domain 0.005621
234 COG2151 metal-sulfur cluster biosynthetic enzyme 0.005602
235 COG2405 1,4-dihydroxy-2-naphthoyl-CoA synthase activity 0.005597
236 COG0615 ADP-L-glycero-beta-D-manno-heptose biosynthetic process 0.005594
237 COG2112 serine threonine protein kinase 0.005590
238 COG1343 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette 0.005571
239 COG2047 protein (ATP-grasp superfamily) 0.005571
240 COG1420 regulation of RNA biosynthetic process -0.005569
241 COG0329 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) -0.005564
242 COG0530 calcium, potassium:sodium antiporter activity 0.005564
243 COG0052 Belongs to the universal ribosomal protein uS2 family -0.005556
244 COG0371 Dehydrogenase 0.005545
245 COG3270 Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA 0.005538
246 COG0632 four-way junction helicase activity -0.005533
247 COG2255 four-way junction helicase activity -0.005533
248 COG1945 arginine decarboxylase activity 0.005517
249 COG2334 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response -0.005504
250 COG2001 Belongs to the MraZ family -0.005475